Dr. Neha Rani

Designation: Associate Professor

Medical Reg. No.: PHA 2280616

Departments: Pharmacology

Educational Qualification

Education

M.Sc, Ph.D. (Pharmacology)

Area Of Interest

Area Of Interest

Cardiovascular and Diabetes research

Research & Projects

Research in progress
Research Completed	Pharmacological approaches to investigate the effect of chrysin on experimental models of myocardial infarction in streptozotocin-induced diabetic rats (Ph. D. Thesis Work). Studies on the cardioprotective effect of naringin in the experimental model of ischemia-reperfusion injury in rat heart (M.Sc. Thesis work)
Award	CL Malhotra Award, APPICON, Patna, 21th -24th October, 2016 Prof. RC Shukla Oration Award, APPICON, Jodhpur, 26th -28th November, 2015 Second Prize (Cash Prize of Rs. 25,000) – AIIMS Excellence Research Award 2014 under Basic Research Category Recipient of Ranga Travel Grant, AIIMS, New Delhi, 2015 Recipient of Mrs. Dwarka Prasad Travel Grant, AIIMS, New Delhi, 2015 Recipient of Prestigious “INSPIRE FELLOWSHIP”, Department of Science and Technology, New Delhi, Govt. of India, 2012-2015 First Position in Ph.D. (Pharmacology) entrance examination, AIIMS, New Delhi , July 2012 First position in M.S (Master of Science, Pharmacology), 2010-2012, AIIMS, New Delhi, India Second Rank in B. Pharmacy Haryana State Entrance examination, July 2007 Scholarship from 2005 to 2007 for securing 3rd rank in D. Pharmacy entrance exam Letter of Appreciation for actively participating on 57th Institute Day Exhibition, 25-27th September, 2012

Publications

Rani N, Bharti S, Tomar A, Dinda AK, Arya DS, Bhatia J.Inhibition of PARP activation by enalapril is crucial for its renoprotective effect in cisplatin-induced nephrotoxicity in rats. Free Radic Res. 2016;50(11):1226-1236. Rani N, Bharti S, Bhatia J, Nag TC, Ray R, Arya DS. Chrysin, a PPAR-γ agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation. Chem Biol Interact 2016;250:59-67. Rani N, Bharti S, Manchanda M, Nag TC, Ray R, Chauhan SS, Kumari S, Arya DS. Regulation of heat shock proteins 27 and 70, p-Akt/p-eNOS and MAPKs by naringin dampens myocardial injury and dysfunction in vivo after ischemia/reperfusion. PLOS One 2013;8:e82577. Rani N, Bharti S, Bhatia J, Tomar A, Nag TC, Ray R, Arya DS. Inhibition of TGF-β by a novel PPAR-γ agonist, chrysin, salvages β-receptor stimulated myocardial injury in rats through MAPKs-dependent mechanism. Nutr Metab (Lond) 2015;12:11. Rani N, Bharti S, Krishnamurthy B, Bhatia J, Sharma C, Kamal MA, Ojha S, Arya DS. Pharmacological Properties and Therapeutic Potential of Naringenin: A Citrus Flavonoid of Pharmaceutical Promise. Curr Pharm Des. 2016;22(28):4341-59. Krishnamurthy B1, Rani N1, Bharti S, Golechha M, Bhatia J, Nag TC, Ray R, Arava S, Arya DS. Febuxostat ameliorates doxorubicin-induced cardiotoxicity in rats. Chem Bio Inter 2015;237:96-103 [EQUAL AUTHORSHIP] Bharti S, Rani N, Bhatia J, Arya DS. 5-HT2B receptor blockade attenuates β-adrenergic receptor-stimulated myocardial remodeling in rats via inhibiting apoptosis: role of MAPKs and HSPs. Apoptosis 2015;20(4):455-65 Mehra S, Kumar M, Manchanda M, Singh R, Thakur B, Rani N, Arava S, Narang R, Arya DS, Chauhan SS. Clinical significance of cathepsin L and cathepsin B in dilated cardiomyopathy. Mol Cell Biochem. 2017 Jan 10. Ojha S, Bharti S, Golechha M, Sharma AK, Rani N, Kumari S, Arya DS. Andrographispaniculata extract protect against isoproterenol-induced myocardial injury by mitigating cardiac dysfunction and oxidative injury in rats. Acta Pol Pharm 2012;69:269-278. Ojha S, Bharti S, Sharma AK, Rani N, Bhatia J, Kumari S, Arya DS. Effect of Inularacemosa root extract on cardiac function and oxidative stress against isoproterenol-induced myocardial infarction. Indian J Biochem Biophys. 2011;48:22-28. Bharti S, Rani N, Krishnamurthy B, Arya DS. Pre-clinical evidence for the pharmacological actions of naringin: A review. Planta Medica 2014; 80: 437-451. Chapter in Books: Krishnamurthy B, Rani N, Bharti S, Arya DS. Phytopharmaceuticals in Cardiovascular Disorders. Indian Council of Medical Research, New Delhi. 2014 [Accepted in Press] Khan SI, Malhotra RK, Rani N, Sahu AK, Tomar A, Garg S, Nag TC, Ray R, Ojha S, Arya DS, Bhatia J. Febuxostat Modulates MAPK/NF-κBp65/TNF-α Signaling in Cardiac Ischemia-Reperfusion Injury. Oxid Med Cell Longev.2017;2017:8095825 1. Rani N, Arya DS. Chrysin rescues rat myocardium from ischemia-reperfusion injury via PPAR-γ/Nrf2 activation. Eur J Pharmacol. 2020 Sep 15;883:173389. doi: 10.1016/j.ejphar.2020.173389. Epub 2020 Jul 22. PMID: 32707190 2. Deb T, Ghosh A, Dalai CK, Rani N*. Impact of Climatic Variations on Drug-induced skin Reactions in two Different Regions of India. Curr Drug Saf. 2020 Aug 24. doi: 10.2174/1574886315999200824121818. Epub ahead of print. PMID: 32838721. [Corrosponding author].